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Volume 02, Issue 01
Decipher Ayurveda | Volume 02| Issue 01| Jan to Jun 2026
5 articles · July 2026
Research article
Ajay Kumar, Yogesh Kumar, Shubham Pratap Singh
Many synthetic and herbal APIs have been patented as nanosized emulsified gels for a range of medicinal purposes in the last few years. Unfortunately, due to their restricted therape utic utility, almost half of these medications are classified as either class II or class IV in the biopharmaceutical categorization system (BCS) or are neither of them still in development. Benzocaine which is a BCS Class II drug is utilized in this study . Nigella sativa a well - known plant having various medicinal properties is also utilized. This study aimed to determine the efficacy of Benzocaine and Nigella Sativa seed oil against Gram - negative and Gram - positive microorganisms, such as Escherichia coli and Staphylococcus Aureus, as well as to observe the zone of inhibition and create a nanoemulgel to produce the combined impact of synergy. A formulation comprising nanosized emulsion globules created using low - speed homogenization procedures is known as n ano emulsion - based gel, or nanoemulgel, and is further transformed into nanoemulgel by including an appropriate gelling agent. It has been proven to be a viable option for topical medication delivery with globular size ranging between 5 to 500 nm. FTIR was used to study any possible incompatibilities with the drug and other excipients used in the nanoemulgel formulation. Other parameters i.e. viscosity, pH, spreadability, etc are also evaluated to confirm the safety and efficacy of the formulation. The part icle size of the optimized nanoemulsion was found to be 10.6 nm and the zeta potential was around - 10.2 mV. An antimicrobial evaluation was conducted, and the competitive synergistic effect of nanoemulgel was observed. It was determined that benzocaine and Nigella Sativa seed extract separately exhibited just a negligible amount of antibacterial action against both Gramm Positive and Gramm Negative bacteria. The nanoemulgel demonstrated a competent combined effect after being blended.
BenzocaineNigella SativaNanoemulsionNanoemulgelStaphylococcus Aureus
Review article
Anuj Mittal
Fast-dissolving tablets (FDTs), (ODTs) or (MDT s) are one of the most sophisticated types in oral solid dosage form. This study includes developments in formulation, excipient use, manufacturing technologies, QC approaches, and therapeutic uses. FDTs disintegrate in the mouth within 60 seconds without needing water. It is significantly beneficial for patients with dysphagia, pediatric, geriatric and psychiatric individuals. The market for orally disintegrating tablets was expected to increase from USD 14.3 billion to USD 29.0 billion by 2033. It reflect s an expected compound annual growth rate of 8.2%. This study exhaustively analyses various production methods as direct compression, lyophilisation, spray drying, sublimation and three - dimensional (3D) printing. A new excipient system involving synthetic super-disintegrants and natural gums is able to mask taste using microencapsulation, ion - exchange resins, and cyclodextrin complexation . The essential incorporation of the Quality by Design (QbD) approach, which cover Design of Experiments (DoE), response surface methodology, and the Quality Target Product Profile (QTPP) framework. Particular emphasis is given to nanotechnology - based FDTs, comprising formulations loaded with nanoparticles and lipid carriers with nanostructures, which have significantly improved the bioavailability of BCS Class II and IV medications. This review offers pharmaceutical scientists, formulation specialists, and regulatory experts a definitive, evidence - based resource on the current advancements in fast - dissolving tablet technology.
Fast dissolving tabletsorally disintegrating tabletssuperdisintegrantstaste maskinglyophilization
Research article
Riya Mehra, Pragati Triphati, Abhijeet Ojha, Arun Kumar, Vikas Bhatt, Goswami Mamta
The damaging effects of ultraviolet (UV) radiation on the skin include skin burns, photoaging, hyperpigmentation, and skin cancer. Sunscreens are extensively utilized for UV protection. Herbal sunscreens have recently been con sidered because of their safety, antioxidant potential, and fewer side effects. The flowers of Rhododendron barbatum contain flavonoids, phenolics, tannins, and saponins that impart photoprotective properties to the flowers. Hydroalcoholic extraction was c arried out using a maceration process, where ethanol and water were used in 70:30 ratio. The phytochemical analysis was undertaken on R. barbatum flowers. Three different formulations were used (F1, F2, and F3). These were screened against various paramete rs, including colour, pH, spreadability, washability, stability, and patch tests, and SPF determination using the Mansur equation. Phytochemical screening revealed the presence of flavonoids, phenolics, tannins, and saponins. All formulations exhibited goo d physicochemical properties. Among the formulations, F3 was most homogeneous, spreadable, and stable. The patch test revealed that the formulation was non irritating. In the SPF evaluation, F3 provided an SPF value of approximately 8. The SPF activity is due to the presence of flavonoids and phenols that exhibit good antioxidant properties and UV absorptive properties. This helps prevent oxidative stress and UV - induced damage. The enhanced activity exhibited by formulation F3 can be attributed to the highe r concentration of extracts present in this formulation. The herbal sunscreen cream was chemically and physically stable, safe, and showed moderate photoprotective efficacy. Therefore, it can be considered an alternative to artificial sunscreen creams.
Herbal sunscreenRhododendron barbatumultraviolet radiationSPFflavonoids
Research article
Sweta Goel, Sumit Panwar
Glioblastoma multiforme (GBM) GBM is one of the most aggressive primary brain tumours, with a median survival of less than 15 months with conventional chemoradiotherapy, in part because of the hypo - permeable blood - brain barrier (BBB) and tumour heterogeneity. Addressing these problems, a targeted drug delivery system (NDDS) based on nanoparticles has been developed to achieve site - specific accumulation, control payload release and minimize systemic toxicity. This systematic review and meta - analysis assessed the effectiveness and safety of nanoparticle based NDDS in the treatment of GBM in both preclinical and clinical settings. Nanosystems tested were polymeric nanoparticles, PEGylated liposomes, solid lipid nanoparticles, dendrimers, and transferrin - functionalized nanosystems. Pooled preclinical data showed that the median tumour volume reduction was 68.4% higher than free - drug controls, with the best particle size being between 80 and 180nm and the highest encapsulation efficiency was more than 85%. U87MG cell lines showed IC50 values with temozolomide loaded PLGA nanoparticles at 12.3 µM compared to 47.8 µM free drug. The drug release profiles were sustained for 72 to 96 hours in all cases. In clinical studies, progression - free survival was reported to be 34% longer, and there were no more grade 3 or 4 adverse events, with most being grade 1 – 2. The results suggest that receptor - targeted platforms of nanoparticles are a paradigm shift in GBM pharmacotherapy. To expedite translation, future studies should focus on BBB - penetrating active targeting, uniform toxicological models and adaptive clinical trial designs.
Glioblastoma multiformebrain tumourstemozolomidenanoparticlestoxicological
Review article
Lovely Sharma
Conventional antidiabetic drug delivery systems often suffer from enzymatic degradation, low oral bioavailability, and poor patient compliance. These limitations necessitate innovative, non-invasive, and efficient delivery strategies to maintain optimal glycemic control. It provides an in-depth analysis of next-generation drug delivery technologies for diabetes specifically nanoparticles, hydrogels, and phytosomes highlighting their design principles, therapeutic potential, and translational readiness. Polymeric and lipid nanoparticles improve insulin and drug stability, enhance epithelial permeability, and enable sustained release. Hydrogels especially glucose responsive and microneedle integrated ones offer stimuli triggered insulin release with high biocompatibility. Phytosome formulations significantly enhance bioavailability and clinical performance of herbal bioactives like berberine, curcumin, and quercetin. The integration of nanocarrier engineering, smart polymer design and lipid phytochemical conjugation is reshaping diabetes therapeutics toward needle free, self-regulated, and patient-friendly solutions. These technologies hold immense promise for future clinical translation.
Diabetes mellitusinsulin deliverynanoparticleshydrogelsphytosomes
