Open Access Double-blind peer review da@innovesenjournals.in

Decipher Ayurveda

e-ISSN 3107-8214 · Published by Innovesen Journals

Home / Proceedings of ICIRIPAS 2026; Special Issue-01 / Research article

Research article

“BIOACTIVE PHYTOCHEMICALS OF GLYCYRRHIZA GLABRA FOR TOPICAL ANTI-AGING APPLICATIONS: MOLECULAR MECHANISMS, COSMOECEUTICAL POTENTIAL AND FUTURE PERSPECTIVES”

Anamika Singh* Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India. & Faculty, Raja Balwant Singh Engineering Technical, Campus, BichPuri Agra Uttar Pradesh, India
Dr. Anurag Verma Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India. & Faculty, Raja Balwant Singh Engineering Technical, Campus, BichPuri Agra Uttar Pradesh, India
Dr. Prashant Kumar Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India. & Faculty, Raja Balwant Singh Engineering Technical, Campus, BichPuri Agra Uttar Pradesh, India
Issue Proceedings of ICIRIPAS 2026; Special Issue-01 Published 18 Sep 2026 Language ENG Views 33
Abstract

India is blessed to have enormous plants having healing capacity which are even documented in many traditional systems like Ayurveda with examples tulsi, neem , ashwgandha and many others including the research plant named Glycyrrhiza glabra (mulethi). This plant Glycyrrhiza glabra is used in treatment of many health issues like sore throat, stomach ulcers, respiratory health support etc.
It contains anti-oxidants and active compounds like glabridin, glycyrrhizin and licochalcone A used by several herbal dermatologists for skin pigmentation and rejuvenation with specific anti-aging for wrinkles. Anti-oxidants like glabridin, glycyrrhizin and licochalcone A follows signaling pathways, reducing oxidative stress and also suppresses inflammation. They inhibits enzymes like 11beta-HSD2 and MAPK signaling. Glabridin stops tyrosinase activities for age related hyper-pigmentation Glycyrrhizin elevate superoxide dismutase (SOD) activity.
By utilizing nanotechnology ,the scientists these days focusses more on advanced drug pattern, green industrial bio-composites and in in specific nano-medicines. Many innovations are required in targeting drug resistant viral strains and inhibit cancer cells proliferation.

Keywords
Glycyrrhiza glabra or liquoriceCosmeceuticalsAnti-ageingAnti-microbialEnzyme inhibitionDepigmentation.
How to cite

Anamika Singh*, Dr. Anurag Verma, Dr. Prashant Kumar. (2026). “BIOACTIVE PHYTOCHEMICALS OF GLYCYRRHIZA GLABRA FOR TOPICAL ANTI-AGING APPLICATIONS: MOLECULAR MECHANISMS, COSMOECEUTICAL POTENTIAL AND FUTURE PERSPECTIVES”. Decipher Ayurveda, Special Issue(ICIRIPAS Proceedings).